KMID : 0854720080280020152
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Korean Journal of Asthma, Allergy and Clinical Immunology 2008 Volume.28 No. 2 p.152 ~ p.155
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A Case of Occupational Asthma Caused by Cefotiam (Fontiam¨Þ) in a Nurse
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Ryu Hwan-Cheol
Shin Bong-Chul Seo Hyo-Rim Kim Bo-Kyung Heo Jeong-Hun Yang Doo-Kyung Lee Soo-Keol Son Choon-Hee Park Hae-Sim Lee Su-Mi Koo Tae-Hyung
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Abstract
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Cephalosporins are well-known agents that may cause occupational asthma. There have been a few reports suggesting that its pathogenesis may be IgE-mediated. To the best of our knowledge, this is the first report of cefotiam-induced occupational asthma. A 36-year-old female, a nurse, visited our allergy department for the evaluation of occupational asthma. She had worked in the surgical inpatients¡¯ ward and handled a few kinds of antibiotics for 4 years. At that time, she developed rhinorrhea, paroxysmal cough and chest tightness for 2 months. Her symptoms used to be aggravated during and shortly after her work and subsided several hours after work. However, her symptoms subsided spontaneously, because she was brought to the outpatients¡¯ ward for recent 3 years. Therefore, she had only mild dyspnea on exercise. Methacholine bronchial challenge test revealed a negative response. The skin prick test with cefotiam (Fontaim(R)) showed a strong positive response and a specific bronchial provocation test with cefotiam demonstrated an early asthmatic response. A few days after bronchial provocation test with cefotiam, the methacholine bronchial challenge test showed a positive response. Further studies will be needed to evaluate the exact pathogenetic mechanism of cefotiam- induced occupational asthma.
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KEYWORD
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OccupationalAsthma, Cefotiam
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